Twelve years before, the Nine-Tailed Demon Fox attacked the ninja village Konohagakure. It raised chaos and slaughtered many people, until the leader of Konohagakure – the Fourth Hokage – sacrificed his own life to seal the demon inside Naruto when he was a newborn.
Konohagakure, however, regarded Naruto as if he were the demon fox itself and mistreated him throughout most of his childhood. A decree made by the Third Hokage forbade anyone to discuss or mention the attack of the demon fox to anyone. However, this did not stop them from treating him like an outcast and as a result he grew up an orphan alone. However, that soon changed after Naruto graduated from the Ninja Academy by using his Shadow Clone Technique, a technique from a forbidden scroll that he was tricked into stealing, to save his teacher, Iruka Umino, from the renegade ninja Mizuki. That encounter gave Naruto two insights: that he was the container of the demon fox, and that there was someone besides the Third Hokage who actually cared for and acknowledged him.
The main story follows Naruto and his friends' personal growth and development as ninja, and emphasizes their interactions with each other and the influence of their backgrounds on their personalities. Naruto finds two friends and comrades in Sasuke Uchiha and Sakura Haruno, two fellow young ninja who are assigned with him to form a three-person team under an experienced sensei named Kakashi Hatake. Naruto also confides in other characters that he meets throughout the series as well. They learn new abilities, get to know each other and other villagers better, and experience a coming-of-age journey as Naruto dreams of becoming the Hokage of Konohagakure.
Throughout all of the Naruto plot, strong emphasis on character development changes the plot, with very few things happening because of chance. At first, emphasis is placed on Naruto, Sasuke, and Sakura, who are the members of Team 7. Later, Orochimaru, a criminal at the top of Konoha's most wanted list, attacks Konoha killing the Third Hokage as an act of revenge. He also desires to acquire Sasuke Uchiha due to his powerful genetic heritage. Believing Orochimaru will be able to give him the strength needed to kill his brother Itachi, who destroyed all his clan, he goes to him. Naruto fights against Sasuke to make him return, but he fails. Naruto does not give up on Sasuke, leaving Konoha for two-and-a-half years of training to prepare himself for the next time he meets Sasuke. After the training period, a mysterious organization called Akatsuki attempts to capture the nine powerful tailed beasts including begins the Nine-Tailed Demon Fox that is sealed inside of Naruto. Several ninjas from Konoha, including Team 7, fight against the Akatsuki members as well as Team 7 search for their teammate Sasuke.